Professor Emeritus
Pathology
Publications
Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma.
American journal of respiratory and critical care medicine
Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma.
Cell genomics
The Type 2 Asthma Mediator IL-13 Inhibits SARS-CoV-2 Infection of Bronchial Epithelium.
American journal of respiratory cell and molecular biology
A simple method to generate human airway epithelial organoids with externally orientated apical membranes.
American journal of physiology. Lung cellular and molecular physiology
Flow Cytometric Analysis and Purification of Airway Epithelial Cell Subsets.
American journal of respiratory cell and molecular biology
The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium.
bioRxiv : the preprint server for biology
Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia.
Developmental cell
Functional Profiling of CFTR-Directed Therapeutics Using Pediatric Patient-Derived Nasal Epithelial Cell Models.
Frontiers in pediatrics
Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection.
Cell reports. Medicine
CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Decreased Immune Activation in Cystic Fibrosis Airway Epithelium Following Lung Transplant.
The Journal of Heart and Lung Transplantation
Efficient RNP-Directed Human Gene Targeting Reveals SPDEF is Required for IL-13-Induced Mucostasis.
American journal of respiratory cell and molecular biology
Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants.
Scientific reports
Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia.
Cells, tissues, organs
Aspiration pneumonia in the setting of diffuse esophageal retention cysts: An autopsy case report.
Human Pathology Case Reports
Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter.
SLAS discovery : advancing life sciences R & D
Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
In vivo and in vitro ivacaftor response in cystic fibrosis patients with residual CFTR function: N-of-1 studies.
Pediatric pulmonology
Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product.
The Journal of biological chemistry
Correlation of Prenatal Diagnosis and Pathology Findings Following Dilation and Evacuation for Fetal Anomalies.
Archives of pathology & laboratory medicine
Cigarette Smoke Mediates Nuclear to Cytoplasmic Trafficking of Transcriptional Inhibitor Kaiso through MUC1 and P120-Catenin.
The American journal of pathology
Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.
The Journal of clinical investigation
Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Chapter 1 The Autopsy—Past and Present.
Autopsy Pathology: A Manual and Atlas
Chapter 10 Supplemental Laboratory Studies.
Autopsy Pathology: A Manual and Atlas
Chapter 11 The Autopsy Report.
Autopsy Pathology: A Manual and Atlas
Chapter 12 Sudden Death Due to Natural Causes.
Autopsy Pathology: A Manual and Atlas
Chapter 13 Multiple Organ Dysfunction and Sepsis.
Autopsy Pathology: A Manual and Atlas
Chapter 14 Death Certification.
Autopsy Pathology: A Manual and Atlas
Chapter 15 Quality Management.
Autopsy Pathology: A Manual and Atlas
Chapter 16 Atlas of Gross Autopsy Pathology.
Autopsy Pathology: A Manual and Atlas
Chapter 2 Legal, Social, and Ethical Issues.
Autopsy Pathology: A Manual and Atlas
Chapter 3 Autopsy Biosafety.
Autopsy Pathology: A Manual and Atlas
Chapter 4 Basic Postmortem Examination.
Autopsy Pathology: A Manual and Atlas
Chapter 5 Postmortem Examination of Fetuses and Infants.
Autopsy Pathology: A Manual and Atlas
Chapter 6 Special Dissection Procedures.
Autopsy Pathology: A Manual and Atlas
Chapter 7 Autopsy Photography and Radiology.
Autopsy Pathology: A Manual and Atlas
Chapter 8 Microscopic Examination.
Autopsy Pathology: A Manual and Atlas
Chapter 9 Microscopic Findings.
Autopsy Pathology: A Manual and Atlas
Preface.
Autopsy Pathology: A Manual and Atlas
Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action.
Molecular pharmacology
Less toxic method for producing giant paper organ sections for pathology and anatomy education.
Pathology and Laboratory Medicine International
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.
Science translational medicine
Pivotal role of MUC1 glycosylation by cigarette smoke in modulating disruption of airway adherens junctions in vitro.
The Journal of pathology
Growth of alveoli during postnatal development in humans based on stereological estimation.
American journal of physiology. Lung cellular and molecular physiology
Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma.
American journal of respiratory and critical care medicine
Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.
Molecular pharmacology
Anchored PDE4 controls CFTR conductance in normal and cystic fibrosis airway epithelia (1181.3).
The FASEB Journal
Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Distribution and size of mucous glands in the ferret tracheobronchial tree.
Anatomical record (Hoboken, N.J. : 2007)
Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways.
The American journal of pathology
Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1.
The Journal of pathology
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Proceedings of the National Academy of Sciences of the United States of America
Airway epithelial miRNA expression is altered in asthma.
American journal of respiratory and critical care medicine
Chloride secretion by cultures of pig tracheal gland cells.
American journal of physiology. Lung cellular and molecular physiology
p120-catenin modulates airway epithelial cell migration induced by cigarette smoke.
Biochemical and biophysical research communications
Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells.
American journal of physiology. Lung cellular and molecular physiology
64* Correction o ?F508-CFTR in human airway epithelia and ex vivo rectal biopsies by s-cis-locked bithiazole corrector-29.
Journal of Cystic Fibrosis
Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype.
American journal of physiology. Lung cellular and molecular physiology
Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells.
The American journal of pathology
CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures.
Molecular biology of the cell
Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection.
American journal of respiratory cell and molecular biology
Cultures of human tracheal gland cells of mucous or serous phenotype.
In vitro cellular & developmental biology. Animal
Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism.
The Journal of biological chemistry
Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function.
American journal of physiology. Lung cellular and molecular physiology
In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects.
The Journal of allergy and clinical immunology
In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye.
The Journal of biological chemistry
In utero and postnatal exposure to environmental tobacco smoke (ETS) alters alveolar and respiratory bronchiole (RB) growth and development in infant monkeys.
Toxicologic pathology
Chapter 1 The Autopsy—Past and Present.
Autopsy Pathology
Chapter 10 The Autopsy Report.
Autopsy Pathology
Chapter 13 Death Certification.
Autopsy Pathology
Chapter 15 Atlas of Autopsy Pathology.
Autopsy Pathology
Chapter 2 Legal, Social, and Ethical Issues.
Autopsy Pathology
Chapter 3 Autopsy Biosafety.
Autopsy Pathology
Chapter 4 Basic Postmortem Examination.
Autopsy Pathology
Chapter 5 Postmortem Examination of Fetuses and Infants.
Autopsy Pathology
Chapter 6 Special Dissection Procedures.
Autopsy Pathology
Chapter 7 Autopsy Photography and Radiology.
Autopsy Pathology
Chapter 8 Microscopic Examination.
Autopsy Pathology
Chapter 9 Supplemental Laboratory Studies.
Autopsy Pathology
Preface.
Autopsy Pathology
Transforming Growth Factor-ß1 Inhibits CFTR-dependent cAMP-stimulated Alveolar Epithelial Fluid Transport: Critical Role of Interleukin-8.
The FASEB Journal
Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.
The Journal of clinical investigation
Basolateral Cl channels in primary airway epithelial cultures.
American journal of physiology. Lung cellular and molecular physiology
Differentiated structure and function of primary cultures of monkey oviductal epithelium.
In vitro cellular & developmental biology. Animal
Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit.
The American journal of pathology
Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins.
The Journal of biological chemistry
Differentiated Structure and function of primary cultures of monkey oviductal epithelium.
In Vitro Cellular & Developmental Biology - Animal
Expansion of cultures of human tracheal epithelium with maintenance of differentiated structure and function.
BioTechniques
Submucosal gland dysfunction as a primary defect in cystic fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Disseminated microsporidiosis in a pancreas/kidney transplant recipient.
Archives of pathology & laboratory medicine
Hydroxychloroquine (HCQ) inhibits rhinovirus (RV) replication in cultured human tracheal epithelial cells.
Journal of Allergy and Clinical Immunology
Effects of growth surface on differentiation of cultures of human tracheal epithelium.
In vitro cellular & developmental biology. Animal
Effects of media on differentiation of cultured human tracheal epithelium.
In vitro cellular & developmental biology. Animal
Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts.
The Journal of biological chemistry
Protease XXIV increases detection of mucin gene expression during in situ hybridization in archival tissue.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
A comparative study of mammalian tracheal mucous glands.
Journal of anatomy
Physiology and pathology of tracheobronchial glands.
Respiration physiology
Measurement of fibroblast proliferative activity in bronchoalveolar lavage fluid in the analysis of obliterative bronchiolitis among lung transplant recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Restoration of cyclic adenosine monophosphate-stimulated chloride channel activity in human cystic fibrosis tracheobronchial submucosal gland cells by adenovirus-mediated and cationic lipid-mediated gene transfer.
American journal of respiratory cell and molecular biology
Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation.
American journal of respiratory and critical care medicine
Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells.
The American journal of physiology
Fluid transport across cultures of human tracheal glands is altered in cystic fibrosis.
The Journal of physiology
Effects of ozone on normal and potentially sensitive human subjects. Part I: Airway inflammation and responsiveness to ozone in normal and asthmatic subjects.
Research report (Health Effects Institute)
Fetal congenital cystic adenomatoid malformations of the lung: a clinicopathologic study of eleven cases.
The American journal of surgical pathology
Role of CFTR in chloride secretion across human tracheal epithelium.
The American journal of physiology
Expression of airway secretory epithelial functions by lung carcinoma cells.
In vitro cellular & developmental biology. Animal
Sudden cardiac death and polymorphous ventricular tachycardia in patients with normal QT intervals and normal systolic cardiac function.
The American journal of cardiology
Culture and transformation of human airway epithelial cells.
The American journal of physiology
Chloride secretion and function of serous and mucous cells of human airway glands.
The American journal of physiology
Effects of long-term right ventricular apical pacing on left ventricular perfusion, innervation, function and histology.
Journal of the American College of Cardiology
CFTR in Calu-3 human airway cells: channel properties and role in cAMP-activated Cl- conductance.
The American journal of physiology
Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion.
The American journal of physiology
Use of mucin antibodies and cDNA probes to quantify hypersecretion in vivo in human airways.
American journal of respiratory cell and molecular biology
Extrarenal tissue distribution of CHIP28 water channels by in situ hybridization and antibody staining.
The American journal of physiology
CFTR and other Cl- channels in human airway cells.
The Japanese journal of physiology
CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells.
American journal of respiratory cell and molecular biology
Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy.
The American review of respiratory disease
Reverse transcription-polymerase chain reaction (RT-PCR) phenotypic analysis of cell cultures of human tracheal epithelium, tracheobronchial glands, and lung carcinomas.
American journal of respiratory cell and molecular biology
Altered fluid transport across airway epithelium in cystic fibrosis.
Science (New York, N.Y.)
Effects of nitric acid gas alone or in combination with ozone on healthy volunteers.
The American review of respiratory disease
Calcium-dependent chloride secretion across cultures of human tracheal surface epithelium and glands.
The American journal of physiology
Markers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjects.
The American review of respiratory disease
Cultures of bovine tracheal epithelium with differentiated ultrastructure and ion transport.
In vitro cellular & developmental biology : journal of the Tissue Culture Association
Endomyocardial biopsy findings in a patient with polymyositis-dermatomyositis.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
Primary aortoduodenal fistula caused by severe atherosclerosis, not by aneurysm.
The American journal of cardiovascular pathology
Ablation of ventricular tachycardia using multiple sequential transcatheter application of radiofrequency energy.
Pacing and clinical electrophysiology : PACE
Characterization of immortal cystic fibrosis tracheobronchial gland epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America
Differentiated structure and function of cultures from human tracheal epithelium.
The American journal of physiology
Bovine tracheal serous cell secretion: role of cAMP and cAMP-dependent protein kinase.
The American journal of physiology
Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium.
The American journal of physiology
Changes in permeability of dog tracheal epithelium in response to hydrostatic pressure.
The American journal of physiology
High-resolution CT appearance of diffuse alveolar septal amyloidosis.
AJR. American journal of roentgenology
Altered ion transport by tracheal glands in cystic fibrosis.
The American journal of physiology
Catheter ablation of the atrioventricular junction using a helical microwave antenna: a novel means of coupling energy to the endocardium.
Pacing and clinical electrophysiology : PACE
Ion transport by cultures of human tracheobronchial submucosal glands.
The American journal of physiology
A pound of prevention when there isn't a cure.
Archives of pathology & laboratory medicine
Simple technique for culture of highly differentiated cells from dog tracheal epithelium.
The American journal of physiology
Hyaluronic acid in a cardiac myxoma: a biochemical and histological analysis.
Virchows Archiv. A, Pathological anatomy and histopathology
Etiology of intestinal damage in gastroschisis, II. Timing and reversibility of histological changes, mucosal function, and contractility.
Journal of pediatric surgery
Iodine toxicity secondary to continuous povidone-iodine mediastinal irrigation in dogs.
The Journal of surgical research
Denervation-induced inflammation in the rat.
Neuroscience letters
Takayasu' s Arteritis (Type III) in an 8-Year-Old Girl: A Takayasu's Arteritis (Type III) in an 8-Year-Old Girl: A Multimodality Approach to Staged Revascularization of the Heart, Head, and Abdominal Viscera—A Case Report.
Vascular and Endovascular Surgery
Effect of repetitive brief episodes of cardiac ischemia on 31P magnetic resonance spectroscopy in the cat.
Magnetic resonance in medicine
Effects of multipolar electrode radiofrequency energy delivery on ventricular endocardium.
American heart journal
Receptors on airway gland cells.
The American review of respiratory disease
Intravascular ultrasound: significance of the three-layered appearance of normal muscular arteries.
Journal of the American College of Cardiology
Human tracheobronchial submucosal gland cells in culture.
American journal of respiratory cell and molecular biology
Hyaluronic acid deposition in cardiac myxomas: localization using a hyaluronate-specific binding protein.
The American journal of cardiovascular pathology
The serous cell.
Annual review of physiology
Etiology of intestinal damage in gastroschisis. I: Effects of amniotic fluid exposure and bowel constriction in a fetal lamb model.
Journal of pediatric surgery
Accuracy and reproducibility of clinically acquired two-dimensional echocardiographic mass measurements.
American heart journal
Occlusive and reperfused myocardial infarcts: differentiation with Mn-DPDP--enhanced MR imaging.
Radiology
Mast cell chymase. A potent secretagogue for airway gland serous cells.
Journal of immunology (Baltimore, Md. : 1950)
Characterization of beta-adrenergic receptors in cultured bovine tracheal gland cells.
The American journal of physiology
Catheter ablation of canine myocardium with radiofrequency energy.
Pacing and clinical electrophysiology : PACE
Airway secretion: a cell-specific analysis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40.
Proceedings of the National Academy of Sciences of the United States of America
Characterization of high-energy phosphate compounds during reperfusion of the irreversibly injured myocardium using 31P MRS.
Magnetic resonance in medicine
Information management: emergence of a new deal. Roundtable on information management.
Healthcare financial management : journal of the Healthcare Financial Management Association
Monoclonal antibodies directed against human airway secretions. Localization and characterization of antigens.
The American journal of pathology
Computed tomography: pathologic correlation in lung disease due to tocainide.
The American review of respiratory disease
Glycoconjugates secreted by bovine tracheal serous cells in culture.
Archives of biochemistry and biophysics
Prenatal detection of left atrial isomerism by ultrasound.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
106. Imaging of Myocardial Infarction in Rats Albumin-(Gd-DTPA), a Macromolecular, Blood-Volume Contrast Agent.
Investigative Radiology
Effects of catheter-delivered electrical discharges near the tricuspid anulus in dogs.
Journal of the American College of Cardiology
Magnetic resonance imaging of myocardial infarction using albumin-(Gd-DTPA), a macromolecular blood-volume contrast agent in a rat model.
Investigative Radiology
Verapamil prevents the development of alcoholic dysfunction in hamster myocardium.
Journal of the American College of Cardiology
Prenatal detection of truncus arteriosus by ultrasound.
Pediatric cardiology
Primary cultures of the dog's tracheal epithelium: fine structure, fluid, and electrolyte transport.
Cell and tissue research
Isolated canine mastocytoma cells: propagation and characterization of two cell lines.
The American journal of physiology
Establishment and characterization of a cell line derived from bovine tracheal glands.
In vitro cellular & developmental biology : journal of the Tissue Culture Association
Tracheal carbohydrate antigens identified by monoclonal antibodies.
Archives of biochemistry and biophysics
Neuropeptides degranulate serous cells of ferret tracheal glands.
The American journal of physiology
Perinatal myocardial infarction: a case report and review of the literature.
Pediatric cardiology
Cystic fibrosis decreases the apical membrane chloride permeability of monolayers cultured from cells of tracheal epithelium.
Proceedings of the National Academy of Sciences of the United States of America
Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea.
Proceedings of the National Academy of Sciences of the United States of America
Electrical properties of monolayers cultured from cells of human tracheal mucosa.
Journal of applied physiology (Bethesda, Md. : 1985)
Experimental pulmonary hypoplasia and oligohydramnios: relative contributions of lung fluid and fetal breathing movements.
Journal of pediatric surgery
Monoclonal antibodies as probes for unique antigens in secretory cells of mixed exocrine organs.
Proceedings of the National Academy of Sciences of the United States of America
Congenital (infantile) hemangiopericytoma of the tongue and sublingual region.
American journal of clinical pathology
Endomyocardial biopsy in Henoch-Schönlein purpura.
American heart journal
Kaposi's sarcoma in young homosexual men: a histopathologic study with particular reference to lymph node involvement.
Archives of pathology & laboratory medicine